MSAT Associate Scientist

Summary:
Our client, a biopharmaceutical company located in Cork, is looking for a MSAT Associate Scientist to join their team. The ideal candidate will be focusing on small-scale cell culture and fermentation activities and/or purification processing in the Biologics Centre of Excellence laboratory associated with the commercial manufacturing processes for a range of commercial products. The successful candidate will support process characterization, scale down model development, troubleshooting of complex manufacturing deviations, and continuous process improvement activities.

Responsibilities:

• Technical transfer, development and/or optimisation of small-scale models for cell culture or purification commercial processes.
• Design and conduct laboratory studies to support commercial manufacturing of recombinant enzymes and proteins.
• Studies include but are not limited to; process optimization & robustness studies, resin qualification, new technology evaluation, exploration of process analytical technologies.
• Knowledgeable in protein science, cell biology and protein expression.
• Readily share technical knowledge and experience with the wider MSAT team and support students/graduates with their laboratory skills development.
• Provide technical and investigations support for ongoing cell culture/purification processes at laboratory and manufacturing scale.
• Work cross-functionally with manufacturing, quality, CMC to secure consistency of drug substance supply to our patients.
• Work independently and within a team to maintain daily laboratory operations and actively communicate risks, setbacks and successes to internal stakeholders.
• Work with other MSAT scientists locally and globally to identify knowledge gaps and provide solutions to increase process understanding.
• Effective execution of experiments and basic problem solving with thorough documentation of experiments and results.
• Ability to perform data analysis and interpret and present results. An interest in Advanced Data Analytics with experience in RStudio, JMP, DoE would be desirable.
• Demonstrated excellent verbal and written communications skills and ability to handle multiple tasks with good organizational skills.
• Collaborate locally and globally, practice open & regular communication with key stakeholders within and outside of our client including Process Sciences, Analytical Chemistry, Manufacturing, Quality, Validation, Quality Control, and Facilities Services.
• Adhere to all site safety, environmental and industrial hygiene procedures and practices.
• Play an active role in maintaining and enhancing the safety of the workplace and the laboratories.
• Prepare SOPs, reports and documents such as characterization protocols, development reports, and testing results data reports.
• Coordinate routine preventative maintenance for laboratory equipment.
• Equipment related to analytical testing, as well as cell culture and/or purification equipment typical in biopharmaceutical labs and manufacturing.
• May be responsible for managing one or more associate scientists.

Qualifications & Experience:

• Bachelor’s degree in biochemistry, biotechnology or similar with 3-5 years relevant experience in process development, manufacturing sciences or commercial manufacturing.
• Masters or PhD qualification in a relevant technical area would be an advantage.
• Experience working within a regulated or pharmaceutical environment would be desirable.
• Experience with mammalian or microbial processing and/or purification technologies.
• An interest in Advanced Data Analytics and Design of Experiments with experience in RStudio, SAS, JMP etc would be desirable.